her3 hairy-related 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: her3provided by ZNC
Official Full Name: hairy-related 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-204
See related: Ensembl:ENSDARG00000076857 AllianceGenome:ZFIN:ZDB-GENE-980526-204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: HER-3; sb:eu263
Summary: Enables DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription; negative regulation of neurogenesis; and regulation of embryonic development. Predicted to be active in nucleus. Is expressed in several structures, including DEL; central nervous system; epiblast; midbrain neural keel; and neural plate. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (46641315..46642558)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (46651107..46652327)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish her3 knockout impacts developmental and cancer-related gene signatures.
Title: Zebrafish her3 knockout impacts developmental and cancer-related gene signatures.
Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
Title: The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish.
Links the positional dorsoventral polarity information in the neuroectoderm to the regulation of neurogenesis.
Title: Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm.
Transcription of her3 is repressed rather than activated by Notch signalling.
Title: her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling.

Submit: New GeneRIF Correction

General gene information

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Markers

her2 (e-PCR), detects polymorphism
- UniSTS:204649

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hairy-related 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131080.2 → NP_571155.1 hairy-related 3

See identical proteins and their annotated locations for NP_571155.1

Status: VALIDATED

Source sequence(s)

CU693448

UniProtKB/TrEMBL

Q90465

Related

ENSDARP00000099080.3, ENSDART00000113803.4

Conserved Domains (2) summary

smart00511
Location:88 → 129

ORANGE; Orange domain

cd00083
Location:17 → 77

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...