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    mki67 marker of proliferation Ki-67 [ Danio rerio (zebrafish) ]

    Gene ID: 564521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mki67provided by ZNC
    Official Full Name
    marker of proliferation Ki-67provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9771
    See related
    Ensembl:ENSDARG00000091150 AllianceGenome:ZFIN:ZDB-GENE-030131-9771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb31; sb:cb31; wu:fa11g09; wu:fb57a07; wu:fi14e05; si:ch211-250b22.7
    Summary
    Predicted to be involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including blood; head; pectoral fin bud; pectoral fin musculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mki67 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10367835..10381070, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10329992..10343222, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene NDC80 kinetochore complex component Neighboring gene eukaryotic elongation factor 2 kinase Neighboring gene transfer RNA leucine (anticodon UAG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
    2. hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Sun J, et al. Circulation, 2022 Jul 5. PMID 35652354, Free PMC Article
    3. RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Olson HM, et al. Development, 2024 Jan 1. PMID 38165177, Free PMC Article
    4. leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Shin K, et al. Dev Dyn, 2024 Jan. PMID 36495292,
    5. In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Silva NJ, et al. Nat Commun, 2021 Oct 8. PMID 34625548, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proliferation marker protein Ki-67
    Names
    antigen KI-67-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277446.2 → NP_001264375.1  proliferation marker protein Ki-67

      Status: VALIDATED

      Source sequence(s)
      CR848037, CT730715, CU104767
      UniProtKB/TrEMBL
      A0A8M1NZY3, E7F3N4
      Related
      ENSDARP00000126723.1, ENSDART00000152788.2
      Conserved Domains (4) summary
      cd00060
      Location:8 → 99
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:960 → 1058
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:447 → 484
      PP1_bind; Protein phosphatase 1 binding
      cl26511
      Location:1485 → 2042
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      10367835..10381070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358467.3 → XP_017213956.1  proliferation marker protein Ki-67 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z3I0
    Nucleotide Protein Strain
    Heading Accession and Version

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