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    ccn2b cellular communication network factor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 100124530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccn2bprovided by ZNC
    Official Full Name
    cellular communication network factor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-82
    See related
    Ensembl:ENSDARG00000104292 AllianceGenome:ZFIN:ZDB-GENE-070705-82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctgf; ctgfb; si:ch211-173b8.2
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; positive regulation of cell differentiation; and signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in axis; head; neural plate; notochord posterior region; and trunk. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ccn2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (13801489..13808632, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (13940947..13946437, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488485 Neighboring gene zinc finger CCHC domain-containing protein 12 Neighboring gene erythrocyte membrane protein band 4.1a Neighboring gene tRNA selenocysteine 1 associated protein 1a Neighboring gene syntaxin 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, molecular characterization, and tissue differential expression of connective tissue growth factor (ctgf) of grass carp. Pan WQ, et al. Fish Physiol Biochem, 2019 Aug. PMID 31267430
    2. LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion. Camillo C, et al. J Cell Biol, 2021 Nov 1. PMID 34581723, Free PMC Article
    3. New insights into cardiotoxicity induced by chiral fluoxetine at environmental-level: Enantioselective arrhythmia in developmental zebrafish (Danio rerio). Chai T, et al. Environ Pollut, 2021 Feb 1. PMID 33352483
    4. A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes. Celeghin R, et al. Cell Death Discov, 2023 Dec 6. PMID 38057295, Free PMC Article
    5. Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. Chang SH, et al. BMB Rep, 2023 Sep. PMID 37748761, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CCN family member 2b
    Names
    connective tissue growth factor b
    zCTGF-c19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102573.1 → NP_001096043.1  CCN family member 2b precursor

      See identical proteins and their annotated locations for NP_001096043.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ087331
      UniProtKB/TrEMBL
      A6XA79
      Related
      ENSDARP00000147012.1, ENSDART00000187670.1
      Conserved Domains (4) summary
      smart00209
      Location:197 → 238
      TSP1; Thrombospondin type 1 repeats
      pfam00219
      Location:25 → 77
      IGFBP; Insulin-like growth factor binding protein
      cl17735
      Location:98 → 158
      VWC; von Willebrand factor type C domain
      cl21545
      Location:248 → 331
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      13801489..13808632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173770.5 → XP_005173827.1  CCN family member 2b isoform X1

      See identical proteins and their annotated locations for XP_005173827.1

      UniProtKB/TrEMBL
      A5PN60, C9ELM6
      Related
      ENSDARP00000133091.1, ENSDART00000166895.2
      Conserved Domains (4) summary
      smart00209
      Location:201 → 242
      TSP1; Thrombospondin type 1 repeats
      smart00214
      Location:98 → 157
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:25 → 77
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:252 → 335
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version

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