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    cxxc5a CXXC finger protein 5a [ Danio rerio (zebrafish) ]

    Gene ID: 557911, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cxxc5aprovided by ZNC
    Official Full Name
    CXXC finger protein 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3178
    See related
    Ensembl:ENSDARG00000078865 AllianceGenome:ZFIN:ZDB-GENE-030131-3178
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cxxc5; wu:fc29g12; si:ch211-113h10.2
    Summary
    Predicted to enable methyl-CpG binding activity. Acts upstream of or within heart looping; pronephros development; and sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in atrium; cardiac ventricle; heart rudiment; heart tube; and presumptive mesoderm. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cxxc5a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (28863129..28920223, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (28826435..28883919, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:100829 Neighboring gene uncharacterized LOC137488867 Neighboring gene si:dkeyp-79c2.1 Neighboring gene uncharacterized LOC137488868

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. Kim HY, et al. FASEB J, 2014 Feb. PMID 24136587
    2. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. Kim MS, et al. J Biol Chem, 2010 May 7. PMID 20220130, Free PMC Article
    3. CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish. Peng X, et al. Int J Cardiol, 2016 Jul 1. PMID 27077543
    4. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
    5. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart looping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CXXC-type zinc finger protein 5
    Names
    CXXC finger 5
    CXXC finger 5a
    wid

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      28863129..28920223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_681066.9 → XP_686158.4  CXXC-type zinc finger protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TEN0, E7FC24
      Related
      ENSDARP00000112750.1, ENSDART00000132884.2
      Conserved Domains (1) summary
      pfam02008
      Location:217 → 258
      zf-CXXC; CXXC zinc finger domain

    2. XM_009295514.4 → XP_009293789.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_009293789.1

      UniProtKB/TrEMBL
      A0A2R8Q311, A0A8M3AX14
      Conserved Domains (1) summary
      pfam02008
      Location:217 → 258
      zf-CXXC; CXXC zinc finger domain

    3. XM_009295515.4 → XP_009293790.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_009293790.1

      UniProtKB/TrEMBL
      A0A2R8Q311, A0A8M3AX14
      Conserved Domains (1) summary
      pfam02008
      Location:217 → 258
      zf-CXXC; CXXC zinc finger domain

    4. XM_005161382.5 → XP_005161439.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005161439.1

      UniProtKB/TrEMBL
      A0A2R8Q311, A0A8M3AX14
      Related
      ENSDARP00000147051.1, ENSDART00000180820.1
      Conserved Domains (1) summary
      pfam02008
      Location:217 → 258
      zf-CXXC; CXXC zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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