egfl6 EGF-like-domain, multiple 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: egfl6provided by ZNC
Official Full Name: EGF-like-domain, multiple 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-157
See related: Ensembl:ENSDARG00000045958 AllianceGenome:ZFIN:ZDB-GENE-040718-157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb3; maeg; sb:cb3; zgc:92328; wu:fc66b04
Summary: Enables integrin binding activity and receptor ligand activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and regulation of sprouting angiogenesis. Acts upstream of or within several processes, including intracellular signaling cassette; positive regulation of sprouting angiogenesis; and regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including fin; median fin fold; pharyngeal arch; rhombomere; and somite. Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (54629937..54679574)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (54688207..55090061)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation.
Title: Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation.
Results demonstrate that Maeg promotes angiogenesis dependent on RGD domain and stimulates activation of Akt and Erk signaling suggesting that Maeg promotes angiogenesis via additional signaling pathway more than Notch.
Title: The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.
Egfl6 is involved in zebrafish notochord development
Title: Egfl6 is involved in zebrafish notochord development.

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General gene information

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Markers

fj62g02.x1 (e-PCR)
- UniSTS:188747

AI883216 (e-PCR)
- UniSTS:205962

AI878761/AS12 (e-PCR)
- UniSTS:205965

fb03h05.y1 (e-PCR)
- UniSTS:189847

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	TAS Traceable Author Statement more info	PubMed
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: epidermal growth factor-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.