cthrc1a collagen triple helix repeat containing 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cthrc1aprovided by ZNC
Official Full Name: collagen triple helix repeat containing 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040808-22
See related: Ensembl:ENSDARG00000087198 AllianceGenome:ZFIN:ZDB-GENE-040808-22
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101075
Summary: Acts upstream of or within cell adhesion; convergent extension involved in axis elongation; and gastrulation. Predicted to be part of collagen trimer. Is expressed in several structures, including axis; corneal endothelium; margin; musculature system; and shield. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (collagen triple helix repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (12915498..12927098)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (12995970..13007561)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish Cthrc1a is expressed in hypoblast cells, and is required for cell adhesion and migration during gastrulation
Title: Collagen triple helix repeat containing 1a (Cthrc1a) regulates cell adhesion and migration during gastrulation in zebrafish.

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General gene information

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Markers

fa31g09.s1 (e-PCR)
- UniSTS:202514

fk37c08.x1 (e-PCR)
- UniSTS:200929

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: collagen triple helix repeat-containing protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.