wdr74 WD repeat domain 74 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr74provided by ZNC
Official Full Name: WD repeat domain 74provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-1138
See related: Ensembl:ENSDARG00000061993 AllianceGenome:ZFIN:ZDB-GENE-060929-1138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153363
Summary: Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (27052677..27058986)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (27090964..27097273)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076563.1 → NP_001070031.1 WD repeat-containing protein 74

See identical proteins and their annotated locations for NP_001070031.1

Status: PROVISIONAL

Source sequence(s)

BC124328

UniProtKB/TrEMBL

Q08C95

Related

ENSDARP00000083528.5, ENSDART00000089095.6

Conserved Domains (3) summary

COG2319
Location:52 → 325

WD40; WD40 repeat [General function prediction only]

sd00039
Location:44 → 82

7WD40; WD40 repeat [structural motif]

cl02567
Location:137 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...