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    mknk2b MAPK interacting serine/threonine kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 373121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mknk2bprovided by ZNC
    Official Full Name
    MAPK interacting serine/threonine kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-2
    See related
    Ensembl:ENSDARG00000015164 AllianceGenome:ZFIN:ZDB-GENE-030829-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mknk2; wz5090; wu:fb37e05
    Summary
    Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mknk2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (20438889..20449541)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (20406804..20417456)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene MOB kinase activator 3A Neighboring gene REX1, RNA exonuclease 1 homolog Neighboring gene diencephalon/mesencephalon homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Liver transcriptome changes in zebrafish during acclimation to transport-associated stress. Dhanasiri AK, et al. PLoS One, 2013. PMID 23762281, Free PMC Article
    2. A transcriptomics-based analysis of the toxicity mechanisms of gabapentin to zebrafish embryos at realistic environmental concentrations. He Y, et al. Environ Pollut, 2019 Aug. PMID 31121539
    3. Mitochondrial Dysfunction, Disruption of F-Actin Polymerization, and Transcriptomic Alterations in Zebrafish Larvae Exposed to Trichloroethylene. Wirbisky SE, et al. Chem Res Toxicol, 2016 Feb 15. PMID 26745549
    4. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Iovine MK, et al. Genomics, 2002 Jun. PMID 12036288
    5. MNK2 deficiency potentiates β-cell regeneration via translational regulation. Karampelias C, et al. Nat Chem Biol, 2022 Sep. PMID 35697798, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 2b
    Names
    MAP kinase interacting serine/threonine kinase 2b
    MAP kinase-interacting serine/threonine kinase 2
    NP_919383.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194402.1 → NP_919383.1  MAP kinase-interacting serine/threonine-protein kinase 2b

      See identical proteins and their annotated locations for NP_919383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044375
      UniProtKB/TrEMBL
      Q803R1
      Related
      ENSDARP00000019044.5, ENSDART00000016422.8
      Conserved Domains (2) summary
      smart00220
      Location:84 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:82 → 369
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      20438889..20449541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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