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    rhobtb2b Rho related BTB domain containing 2b [ Danio rerio (zebrafish) ]

    Gene ID: 565844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rhobtb2bprovided by ZNC
    Official Full Name
    Rho related BTB domain containing 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071125-1
    See related
    Ensembl:ENSDARG00000089340 AllianceGenome:ZFIN:ZDB-GENE-071125-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See rhobtb2b in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (42690058..42714941)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (42861615..42886646)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 1b Neighboring gene stanniocalcin 1, like Neighboring gene aspartate rich 1 Neighboring gene L antigen family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Li S, et al. Front Cell Dev Biol, 2021. PMID 33898465, Free PMC Article
    2. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      42690058..42714941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358113.3 → XP_017213602.2  rho-related BTB domain-containing protein 2

      UniProtKB/TrEMBL
      A0A8M6Z0X0, E7F6W1
      Related
      ENSDARP00000108618.1, ENSDART00000123496.3
      Conserved Domains (4) summary
      cd01873
      Location:24 → 218
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:487 → 579
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:270 → 310
      BTB; BTB/POZ domain
      cl28614
      Location:412 → 456
      BTB; Broad-Complex, Tramtrack and Bric a brac
    Nucleotide Protein Strain
    Heading Accession and Version

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