mideasa mitotic deacetylase associated SANT domain protein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mideasaprovided by ZNC
Official Full Name: mitotic deacetylase associated SANT domain protein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-151
See related: Ensembl:ENSDARG00000011445 AllianceGenome:ZFIN:ZDB-GENE-041001-151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: elmsan1a; si:dkey-12h9.13
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in telencephalon. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (25886022..25902178, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (25986944..26003248, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitotic deacetylase associated SANT domain protein a

Names: ELM2 and Myb/SANT-like domain containing 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045193.1 → NP_001038658.1 mitotic deacetylase associated SANT domain protein a

Status: PROVISIONAL

Source sequence(s)

AL954831

UniProtKB/TrEMBL

A0A8M1NAG3, F1QTE0

Related

ENSDARP00000014069.6, ENSDART00000024821.7

Conserved Domains (2) summary

pfam01448
Location:656 → 707

ELM2; ELM2 domain

cl21498
Location:762 → 805

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

25886022..25902178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160589.5 → XP_005160646.1 mitotic deacetylase associated SANT domain protein a isoform X1

UniProtKB/TrEMBL

A0A8M2B7P9, F6P8Y5

Related

ENSDARP00000116549.2, ENSDART00000142611.4

Conserved Domains (3) summary

smart00717
Location:760 → 805

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:656 → 707

ELM2; ELM2 domain

cl21498
Location:762 → 805

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...