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    rab32a RAB32a, member RAS oncogene family [ Danio rerio (zebrafish) ]

    Gene ID: 378969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab32aprovided by ZNC
    Official Full Name
    RAB32a, member RAS oncogene familyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031006-10
    See related
    Ensembl:ENSDARG00000029036 AllianceGenome:ZFIN:ZDB-GENE-031006-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb914; rab32; zgc:110481; hm:zehn1770
    Summary
    Predicted to enable GTPase activity. Acts upstream of or within notochord cell vacuolation. Predicted to be located in Golgi apparatus; membrane; and vesicle. Predicted to be active in melanosome; mitochondrion; and trans-Golgi network. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; neural crest; retinal pigmented epithelium; and shield. Orthologous to human RAB32 (RAB32, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rab32a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (32009270..32045005, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (32106391..32142126, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 5a (tomosyn) Neighboring gene androglobin Neighboring gene glutamate receptor, metabotropic 1a Neighboring gene CD164 molecule, sialomucin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Notochord vacuoles absorb compressive bone growth during zebrafish spine formation. Bagwell J, et al. Elife, 2020 Jan 29. PMID 31995030, Free PMC Article
    2. Tissue self-organization underlies morphogenesis of the notochord. Norman J, et al. Philos Trans R Soc Lond B Biol Sci, 2018 Sep 24. PMID 30249771, Free PMC Article
    3. Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Garcia J, et al. Curr Biol, 2017 Jul 10. PMID 28648824, Free PMC Article
    4. prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. Olesnicky E, et al. Genesis, 2010 Nov. PMID 20836130, Free PMC Article
    5. Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Park J, et al. Dev Cell, 2019 Oct 7. PMID 31474562, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within notochord cell vacuolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-32a
    Names
    RAB32, member RAS oncogene family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201332.1 → NP_958489.1  ras-related protein Rab-32a

      See identical proteins and their annotated locations for NP_958489.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049531
      UniProtKB/TrEMBL
      Q7ZW88
      Related
      ENSDARP00000032828.3, ENSDART00000034248.6
      Conserved Domains (2) summary
      smart00175
      Location:14 → 183
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:14 → 213
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      32009270..32045005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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