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    sirt3 sirtuin 3 [ Danio rerio (zebrafish) ]

    Gene ID: 558775, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sirt3provided by ZNC
    Official Full Name
    sirtuin 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1762
    See related
    Ensembl:ENSDARG00000035819 AllianceGenome:ZFIN:ZDB-GENE-070112-1762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158774
    Summary
    Predicted to enable NAD+ binding activity and histone deacetylase activity, NAD-dependent. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See sirt3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (57470229..57509476, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (57167246..57207031, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5a Neighboring gene C-C motif chemokine 5-like Neighboring gene dopamine receptor D4b Neighboring gene phosphodiesterase 5A, cGMP-specific, b Neighboring gene MAD2 mitotic arrest deficient-like 1 (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity. Liu X, et al. Proc Natl Acad Sci U S A, 2024 Apr 23. PMID 38635631, Free PMC Article
    2. Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3. Liao G, et al. J Int Med Res, 2020 Oct. PMID 33081556, Free PMC Article
    3. Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Sheng W, et al. Invest Ophthalmol Vis Sci, 2018 Sep 4. PMID 30208422
    4. Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. Ding Q, et al. iScience, 2021 Jun 25. PMID 34142031, Free PMC Article
    5. Daily mitochondrial dynamics in cone photoreceptors. Giarmarco MM, et al. Proc Natl Acad Sci U S A, 2020 Nov 17. PMID 33144507, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
      Title: Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC158774

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD-dependent protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    NP_001073643.1
    XP_009301762.1
    XP_009301763.1
    XP_068078417.1
    XP_068078418.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080174.1 → NP_001073643.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial

      See identical proteins and their annotated locations for NP_001073643.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129442
      UniProtKB/TrEMBL
      A0A8M1NCM7, A1L2B7
      Related
      ENSDARP00000051972.5, ENSDART00000051973.7
      Conserved Domains (1) summary
      cd01408
      Location:101 → 337
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      57470229..57509476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303487.4 → XP_009301762.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A2R8QMP7, A0A8M3AUK3
      Related
      ENSDARP00000153898.1, ENSDART00000187554.1
      Conserved Domains (1) summary
      cd01408
      Location:101 → 337
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    2. XM_009303488.4 → XP_009301763.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M3B4G2
      Conserved Domains (1) summary
      cd01408
      Location:1 → 232
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    3. XM_068222317.1 → XP_068078418.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

    4. XM_068222316.1 → XP_068078417.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X3

      Related
      ENSDARP00000119230.1, ENSDART00000147036.2
    Nucleotide Protein
    Heading Accession and Version

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