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    st6gal2a ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 403116, updated on 4-Jan-2025

    Summary

    Official Symbol
    st6gal2aprovided by ZNC
    Official Full Name
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060322-4
    See related
    Ensembl:ENSDARG00000039335 AllianceGenome:ZFIN:ZDB-GENE-060322-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    st6gal2; St6GalII; ST6Gal II
    Summary
    Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to be involved in sialylation. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system; hatching gland; mesoderm; pleuroperitoneal region; and vent. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See st6gal2a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6009169..6125980)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6031085..6149665)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch73-390b10.2 Neighboring gene PDZ domain containing 1 Neighboring gene teleost multiple tissue opsin 2b Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene ECRG4 augurin precursor a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-galactoside alpha-2,6-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 2
    Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
    ST6Gal-II
    alpha 2,6-ST 2
    beta-galactosamide alpha-2,6-sialyltransferase II
    sialyltransferase 2
    NP_001153386.1
    XP_005168188.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159914.1NP_001153386.1  beta-galactoside alpha-2,6-sialyltransferase 2

      See identical proteins and their annotated locations for NP_001153386.1

      Status: PROVISIONAL

      Source sequence(s)
      CR450794
      UniProtKB/Swiss-Prot
      Q701R2
      UniProtKB/TrEMBL
      A0A8M1NUJ2, F1Q8R8
      Related
      ENSDARP00000148921.1, ENSDART00000192045.1
      Conserved Domains (1) summary
      pfam00777
      Location:283504
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      6009169..6125980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168131.5XP_005168188.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_005168188.1

      UniProtKB/Swiss-Prot
      Q701R2
      UniProtKB/TrEMBL
      A0A8M1NUJ2, F1Q8R8
      Related
      ENSDARP00000057483.2, ENSDART00000057484.5
      Conserved Domains (1) summary
      pfam00777
      Location:283504
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)