tigarb TP53 induced glycolysis regulatory phosphatase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tigarbprovided by ZNC
Official Full Name: TP53 induced glycolysis regulatory phosphatase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-885
See related: Ensembl:ENSDARG00000045858 AllianceGenome:ZFIN:ZDB-GENE-040426-885
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: c12orf5b; zgc:56074; si:ch211-240j22.3
Summary: Enables fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in negative regulation of glycolytic process and regulation of pentose-phosphate shunt. Predicted to act upstream of or within apoptotic process and autophagy. Predicted to be located in mitochondrial outer membrane and nucleus. Predicted to be active in cytosol. Is expressed in brain. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (5156117..5161877)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (5147547..5153307)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of TigarB gives rise to complete normalization of mitochondrial function, with resulting rescue of dopaminergic neurons in pink-/- larvae.
Title: TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-2,6-bisphosphate 2-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pentose-phosphate shunt	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fructose-2,6-bisphosphatase TIGAR B

Names: probable fructose-2,6-bisphosphatase TIGAR B; tp53-induced glycolysis and apoptosis regulator b

NP_956485.1

EC 3.1.3.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.