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    atp2a2a ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393940, updated on 9-Dec-2024

    Summary

    Official Symbol
    atp2a2aprovided by ZNC
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-702
    See related
    Ensembl:ENSDARG00000029439 AllianceGenome:ZFIN:ZDB-GENE-040426-702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atp2a2; zgc:55380
    Summary
    Predicted to enable P-type calcium transporter activity. Acts upstream of or within heart looping and regulation of heart contraction. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See atp2a2a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11687254..11744994)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11649533..11707288)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene formin binding protein 1a Neighboring gene intraflagellar transport 81 homolog Neighboring gene anaphase promoting complex subunit 7 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC55380

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2
    Names
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a
    serca2
    NP_957259.1
    XP_021333895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200965.1NP_957259.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2

      See identical proteins and their annotated locations for NP_957259.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045327
      UniProtKB/TrEMBL
      A0A8M2BEU8, A9C3Q4, Q7ZW18
      Related
      ENSDARP00000042039.6, ENSDART00000042040.8
      Conserved Domains (6) summary
      TIGR01116
      Location:53987
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:782985
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:472
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:604710
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419526
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      11687254..11744994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478220.2XP_021333895.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEU8, A0A8M9QII7, A9C3Q4
      Conserved Domains (1) summary
      cd02083
      Location:5987
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3