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    arhgap35b Rho GTPase activating protein 35b [ Danio rerio (zebrafish) ]

    Gene ID: 564565, updated on 4-Jan-2025

    Summary

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    Official Symbol
    arhgap35bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 35bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-44
    See related
    Ensembl:ENSDARG00000060297 AllianceGenome:ZFIN:ZDB-GENE-060526-44
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgap35; si:ch211-139a5.8
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in Rho protein signal transduction; regulation of axonogenesis; and regulation of cell size. Predicted to act upstream of or within signal transduction. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See arhgap35b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37864703..37881301, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37264550..37281304, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene pannexin 1b Neighboring gene preproinsulin Neighboring gene FXYD domain containing ion transport regulator 2 Neighboring gene transmembrane serine protease 13b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. Lippincott MF, et al. Genet Med, 2022 Dec. PMID 36178483, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell size IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein 35b; rho GTPase-activating protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      37864703..37881301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476553.2 → XP_021332228.1  rho GTPase-activating protein 35

      UniProtKB/TrEMBL
      A0A8M1RIM7, A5PF53, F1R0X6
      Related
      ENSDARP00000079254.4, ENSDART00000084819.5
      Conserved Domains (5) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      cd00882
      Location:29 → 245
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cd04373
      Location:1262 → 1446
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158 → 247
      Ras; Ras family

    2. XM_021476554.2 → XP_021332229.1  rho GTPase-activating protein 35

      UniProtKB/TrEMBL
      A0A8M1RIM7, A5PF53, F1R0X6
      Conserved Domains (5) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      cd00882
      Location:29 → 245
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cd04373
      Location:1262 → 1446
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158 → 247
      Ras; Ras family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394596.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      28613..45211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003198643.6 → XP_003198691.2  rho GTPase-activating protein 35

      See identical proteins and their annotated locations for XP_003198691.2

      UniProtKB/TrEMBL
      A0A8M1RIM7, A5PF53, F1R0X6
      Conserved Domains (5) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      cd00882
      Location:29 → 245
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cd04373
      Location:1262 → 1446
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158 → 247
      Ras; Ras family

    2. XM_009301690.4 → XP_009299965.1  rho GTPase-activating protein 35

      See identical proteins and their annotated locations for XP_009299965.1

      UniProtKB/TrEMBL
      A0A8M1RIM7, A5PF53, F1R0X6
      Conserved Domains (5) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      cd00882
      Location:29 → 245
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cd04373
      Location:1262 → 1446
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158 → 247
      Ras; Ras family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001082843.1: Suppressed sequence

      Description
      NM_001082843.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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