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    wrnip1 WRN helicase interacting protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 405856, updated on 4-Jan-2025

    Summary

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    Official Symbol
    wrnip1provided by ZNC
    Official Full Name
    WRN helicase interacting protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2415
    See related
    Ensembl:ENSDARG00000005218 AllianceGenome:ZFIN:ZDB-GENE-040426-2415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:85976
    Summary
    Predicted to enable enzyme activator activity and single-stranded DNA helicase activity. Predicted to be involved in DNA synthesis involved in DNA repair and DNA-templated DNA replication. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be active in nucleus. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See wrnip1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (374365..389813, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (361498..376946, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33c14.6 Neighboring gene si:dkey-33c14.7 Neighboring gene myosin light chain kinase family, member 4a Neighboring gene uncharacterized LOC137487622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. Babu S, et al. Elife, 2022 Aug 9. PMID 35942692, Free PMC Article
    2. The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Chrystal PW, et al. Genes (Basel), 2021 Jan 26. PMID 33530637, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC85976

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATPase WRNIP1
    Names
    Werner helicase interacting protein 1
    NP_998085.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212920.1 → NP_998085.1  ATPase WRNIP1

      See identical proteins and their annotated locations for NP_998085.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067729
      UniProtKB/TrEMBL
      A0A8M1PFZ7, Q6NW46
      Related
      ENSDARP00000010591.5, ENSDART00000004848.7
      Conserved Domains (5) summary
      PRK13342
      Location:116 → 544
      PRK13342; recombination factor protein RarA; Reviewed
      pfam00004
      Location:154 → 268
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam12002
      Location:391 → 546
      MgsA_C; MgsA AAA+ ATPase C terminal
      pfam16193
      Location:307 → 390
      AAA_assoc_2; AAA C-terminal domain
      cl21455
      Location:134 → 172
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      374365..389813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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