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    tns1b tensin 1b [ Danio rerio (zebrafish) ]

    Gene ID: 555362, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tns1bprovided by ZNC
    Official Full Name
    tensin 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6933
    See related
    Ensembl:ENSDARG00000020845 AllianceGenome:ZFIN:ZDB-GENE-030131-6933
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tns1; fa11e05; wu:fa11e05; si:ch211-148j1.1
    Summary
    Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be located in anchoring junction. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tns1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (47430520..47900099, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (47738107..48152467, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 5b Neighboring gene uncharacterized LOC137496411 Neighboring gene uncharacterized LOC137496502 Neighboring gene G protein-coupled bile acid receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Wang Y, et al. Front Cell Dev Biol, 2020. PMID 33251213, Free PMC Article
    2. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Dina C, et al. Nat Genet, 2015 Oct. PMID 26301497, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tensin 1b; tensin-1
    Names
    tensin 1
    tensin-like C1 domain-containing phosphatase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      47430520..47900099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479035.2 → XP_021334710.1  tensin-1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PT43, A0A8M9QKD7
      Conserved Domains (6) summary
      cd09927
      Location:1491 → 1606
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:208 → 323
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1637 → 1769
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:310 → 436
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28033
      Location:1035 → 1479
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. XM_068223676.1 → XP_068079777.1  tensin-1 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PT47

    3. XM_021479034.2 → XP_021334709.1  tensin-1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QBL4, A0A8M9QG69
      Conserved Domains (7) summary
      cd09927
      Location:1518 → 1633
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:208 → 323
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1664 → 1796
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:310 → 436
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:806 → 1171
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1112 → 1506
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    4. XM_068223675.1 → XP_068079776.1  tensin-1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PT43

    5. XM_021479033.2 → XP_021334708.1  tensin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PT43, A0A8M9Q5A1
      Conserved Domains (6) summary
      cd09927
      Location:1519 → 1634
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:208 → 323
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1665 → 1797
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:310 → 436
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28033
      Location:1063 → 1507
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    6. XM_021479028.2 → XP_021334703.1  tensin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PT47, A0A8M9Q597
      Conserved Domains (7) summary
      cd09927
      Location:1540 → 1655
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:208 → 323
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1686 → 1818
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:310 → 436
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:806 → 1193
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1080 → 1528
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    7. XM_021479027.2 → XP_021334702.1  tensin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PT37, A0A8M9QG69
      Conserved Domains (7) summary
      cd09927
      Location:1546 → 1661
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:208 → 323
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1692 → 1824
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:310 → 436
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:806 → 1199
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1140 → 1534
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    8. XM_021479030.2 → XP_021334705.1  tensin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QG69, A0A8M9QKD3
      Conserved Domains (7) summary
      cd09927
      Location:1538 → 1653
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:200 → 315
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:37 → 83
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1684 → 1816
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:302 → 428
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:798 → 1191
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1132 → 1526
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    9. XM_021479029.2 → XP_021334704.1  tensin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QBL0, A0A8M9QG69
      Conserved Domains (7) summary
      cd09927
      Location:1538 → 1653
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:200 → 315
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:37 → 83
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1684 → 1816
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:302 → 428
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:798 → 1191
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1132 → 1526
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    10. XM_068223677.1 → XP_068079778.1  tensin-1 isoform X11

      UniProtKB/TrEMBL
      A0A8M9QG69

    11. XM_021479036.2 → XP_021334711.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      A0A8M9QG69, A0A8M9QG72
      Related
      ENSDARP00000023241.8, ENSDART00000015159.9
      Conserved Domains (6) summary
      cd09927
      Location:1467 → 1582
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:129 → 244
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1613 → 1745
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:231 → 357
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:727 → 1120
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:1061 → 1455
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    Nucleotide Protein Strain
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