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    ttc4 tetratricopeptide repeat domain 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttc4provided by ZNC
    Official Full Name
    tetratricopeptide repeat domain 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1021
    See related
    Ensembl:ENSDARG00000044405 AllianceGenome:ZFIN:ZDB-GENE-040426-1021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56411; zgc:86801
    Summary
    Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Acts upstream of or within cilium assembly; determination of heart left/right asymmetry; and otolith morphogenesis. Predicted to be active in nucleus. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ttc4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (30676995..30683665, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (30690090..30696700, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene leucine rich adaptor protein 1 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene dynein axonemal intermediate chain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. Xu Y, et al. PLoS One, 2015. PMID 25860617, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56411

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002122.2 → NP_001002122.2  tetratricopeptide repeat protein 4

      Status: VALIDATED

      Source sequence(s)
      BX088595, EH459652, EH504663, EH520549
      UniProtKB/TrEMBL
      Q6IQE3
      Related
      ENSDARP00000065211.5, ENSDART00000065212.6
      Conserved Domains (2) summary
      sd00006
      Location:79 → 107
      TPR; TPR repeat [structural motif]
      cl26005
      Location:40 → 171
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      30676995..30683665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394649.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      149108..157373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201006.1: Suppressed sequence

      Description
      NM_201006.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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