ptgesl prostaglandin E synthase 2-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgeslprovided by ZNC
Official Full Name: prostaglandin E synthase 2-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1063
See related: Ensembl:ENSDARG00000068415 AllianceGenome:ZFIN:ZDB-GENE-040426-1063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptges2; zgc:56527
Summary: Predicted to enable several functions, including glutathione binding activity; heme binding activity; and prostaglandin-E synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in Golgi membrane. Predicted to be active in mitochondrion. Is expressed in female organism; male organism; and reproductive system. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (31008287..31013664)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (30999055..31004432)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E synthase 2

Names: mPGES-2; microsomal prostaglandin E synthase 2

NP_956574.2

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

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These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.