vps45 vacuolar protein sorting 45 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vps45provided by ZNC
Official Full Name: vacuolar protein sorting 45 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-526
See related: Ensembl:ENSDARG00000061180 AllianceGenome:ZFIN:ZDB-GENE-060503-526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-200h23.3
Summary: Acts upstream of or within regulation of lens fiber cell differentiation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (42397287..42416705, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (42827850..42847268, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPS45 normally suppresses lens fiber differentiation in the anterior region of lens epithelium by modulating TGFbeta and canonical Wnt signaling pathways.[Vps45]
Title: Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk47f11.x1 (e-PCR)
- UniSTS:201050

fk38c07.y1 (e-PCR)
- UniSTS:200946

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuolar protein sorting-associated protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256656.1 → NP_001243585.1 vacuolar protein sorting-associated protein 45

Status: VALIDATED

Source sequence(s)

BX571688

UniProtKB/TrEMBL

A0A8M1NZK8, A8E7N5

Related

ENSDARP00000081395.4, ENSDART00000086961.5

Conserved Domains (1) summary

pfam00995
Location:23 → 539

Sec1; Sec1 family