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    mark3b MAP/microtubule affinity-regulating kinase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 767634, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mark3bprovided by ZNC
    Official Full Name
    MAP/microtubule affinity-regulating kinase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-80
    See related
    Ensembl:ENSDARG00000026630 AllianceGenome:ZFIN:ZDB-GENE-060929-80
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153725; si:dkeyp-50f7.6
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mark3b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (43792866..43917727, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (43895788..44020698, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene matrilin-3-like Neighboring gene matrilin 3a Neighboring gene lysosomal protein transmembrane 4 alpha Neighboring gene uncharacterized LOC137488693 Neighboring gene chloride intracellular channel 5b Neighboring gene RUNX family transcription factor 2b Neighboring gene opsin 8, group member a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
    2. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153725

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP/microtubule affinity-regulating kinase 3
    NP_001070043.2
    XP_005170245.1
    XP_005170246.1
    XP_009293196.1
    XP_009293197.1
    XP_009293198.1
    XP_068071661.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076575.2 → NP_001070043.2  MAP/microtubule affinity-regulating kinase 3

      See identical proteins and their annotated locations for NP_001070043.2

      Status: PROVISIONAL

      Source sequence(s)
      CR392340
      UniProtKB/TrEMBL
      A0A8M1NAW9, A2CEF7, F1R0W3
      Related
      ENSDARP00000008926.9, ENSDART00000026213.11
      Conserved Domains (4) summary
      cd12196
      Location:655 → 752
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      43792866..43917727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215560.1 → XP_068071661.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

    2. XM_009294923.4 → XP_009293198.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ALR5
      Conserved Domains (4) summary
      cd12196
      Location:715 → 812
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    3. XM_009294921.4 → XP_009293196.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AL25
      Conserved Domains (4) summary
      cd12196
      Location:735 → 832
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:76 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:345 → 387
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:75 → 327
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    4. XM_009294922.4 → XP_009293197.1  MAP/microtubule affinity-regulating kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B4C1
      Conserved Domains (4) summary
      cd12196
      Location:726 → 823
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:76 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:345 → 387
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:75 → 327
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    5. XM_005170188.5 → XP_005170245.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BHK8
      Conserved Domains (4) summary
      cd12196
      Location:675 → 772
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:76 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:345 → 387
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:75 → 327
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    6. XM_005170189.5 → XP_005170246.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M2BHK1
      Conserved Domains (4) summary
      cd12196
      Location:666 → 763
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:76 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:345 → 387
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:75 → 327
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RNA

    1. XR_002456185.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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