mffb mitochondrial fission factor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mffbprovided by ZNC
Official Full Name: mitochondrial fission factor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-208
See related: Ensembl:ENSDARG00000039203 AllianceGenome:ZFIN:ZDB-GENE-050522-208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:5082098; zgc:110130
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and protein targeting to mitochondrion. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 2. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (11651172..11662927, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (11867573..11879326, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial fission factor homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020566.2 → NP_001018402.2 mitochondrial fission factor homolog A

See identical proteins and their annotated locations for NP_001018402.2

Status: VALIDATED

Source sequence(s)

BC095179, EH441507, EH461639, EH581332

UniProtKB/Swiss-Prot

Q503U3

UniProtKB/TrEMBL

A0A8M2BIG1, A8E7S0

Related

ENSDARP00000120140.1, ENSDART00000145108.2

Conserved Domains (1) summary

pfam05644
Location:12 → 286

Miff; Mitochondrial and peroxisomal fission factor Mff

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

11651172..11662927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171167.4 → XP_005171224.1 mitochondrial fission factor homolog A isoform X1

See identical proteins and their annotated locations for XP_005171224.1

UniProtKB/Swiss-Prot

Q503U3

UniProtKB/TrEMBL

A0A8M2BIG1, A8E7S0

Conserved Domains (1) summary

pfam05644
Location:12 → 286

Miff; Mitochondrial and peroxisomal fission factor Mff
XM_005171168.5 → XP_005171225.1 mitochondrial fission factor homolog A isoform X1

See identical proteins and their annotated locations for XP_005171225.1

UniProtKB/Swiss-Prot

Q503U3

UniProtKB/TrEMBL

A0A8M2BIG1, A8E7S0

Conserved Domains (1) summary

pfam05644
Location:12 → 286

Miff; Mitochondrial and peroxisomal fission factor Mff