U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    snai1a snail family zinc finger 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30273, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    snai1aprovided by ZNC
    Official Full Name
    snail family zinc finger 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-255
    See related
    Ensembl:ENSDARG00000056995 AllianceGenome:ZFIN:ZDB-GENE-990415-255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sna1; cb643; sna-1; snai1; snail1; snail1a; zgc:109820
    Summary
    Enables NF-kappaB binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; epithelial to mesenchymal transition; and mesodermal cell migration. Located in nucleus. Is expressed in several structures, including blastodisc; germ ring; mesoderm; pharyngeal arch; and presumptive mesoderm. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See snai1a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25251493..25257596, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (25013877..25019980, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein a Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta a Neighboring gene microRNA 499a Neighboring gene uncharacterized LOC103911839 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene cylindromatosis (turban tumor syndrome) 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Thisse C, et al. Dev Biol, 1995 Nov. PMID 7589816
    2. Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Weinberg ES, et al. Development, 1996 Jan. PMID 8565839
    3. The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms. Arnaud E, et al. Cell Death Differ, 2006 Jul. PMID 16282981
    4. Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs. Katoh M, et al. Oncol Rep, 2005 Oct. PMID 16142376
    5. Cloning and expression of the quaking gene in the zebrafish embryo. Tanaka H, et al. Mech Dev, 1997 Dec. PMID 9486543

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data support a Snail1-dependent mechanism of BBB disruption and penetration by meningeal pathogens.
      Title: Bacterial induction of Snail1 contributes to blood-brain barrier disruption.
    2. NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
      Title: NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
    3. Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
      Title: Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
    4. Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
      Title: Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.
    5. data suggest that Nrz, in addition to its effect on apoptosis, contributes to cell movements during gastrulation by negatively regulating the expression of Snail-1, a transcription factor that controls cell adhesion
      Title: The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC109820

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration involved in gastrulation IEP
    Inferred from Expression Pattern
    more info
    		  
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    snail family zinc finger 1a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313699.1 → NP_001300628.1  snail family zinc finger 1a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR555298, EH544887
      UniProtKB/TrEMBL
      A7YYC0, F6NH54, Q90274
      Related
      ENSDARP00000111074.2, ENSDART00000123567.3
      Conserved Domains (4) summary
      COG5048
      Location:170 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:201 → 223
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:188 → 211
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001313700.1 → NP_001300629.1  snail family zinc finger 1a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR555298, EH544887
      UniProtKB/TrEMBL
      A7YYC0, F6NH54, Q90274
      Related
      ENSDARP00000111412.2, ENSDART00000130477.4
      Conserved Domains (4) summary
      COG5048
      Location:170 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:201 → 223
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:188 → 211
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      25251493..25257596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131066.1: Suppressed sequence

      Description
      NM_131066.1: This RefSeq was removed because currently there is insufficient support for this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools