gadd45ab growth arrest and DNA-damage-inducible, alpha, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gadd45abprovided by ZNC
Official Full Name: growth arrest and DNA-damage-inducible, alpha, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-60
See related: Ensembl:ENSDARG00000104571 AllianceGenome:ZFIN:ZDB-GENE-040704-60
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gadd45a; zgc:91795
Summary: Predicted to be involved in regulation of cell cycle. Predicted to act upstream of or within DNA damage response. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; choroidal fissure; eye; pancreas primordium; and pronephric mesoderm. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (23935045..23939154)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (23835236..23839345)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide evidence for a coupled mechanism of 5-methylcytosine (5-meC) demethylation, whereby 5-meC deaminase (AID) deaminates 5-meC, followed by thymine base excision by G:T mismatch-specific thymine glycosylase (Mbd4), promoted by Gadd45.
Title: DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest and DNA-damage-inducible, alpha, b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.