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    orai2 ORAI calcium release-activated calcium modulator 2 [ Danio rerio (zebrafish) ]

    Gene ID: 555612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    orai2provided by ZNC
    Official Full Name
    ORAI calcium release-activated calcium modulator 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-127
    See related
    Ensembl:ENSDARG00000035148 AllianceGenome:ZFIN:ZDB-GENE-060531-127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-261j4.7
    Summary
    Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be active in membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Orthologous to human ORAI2 (ORAI calcium release-activated calcium modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See orai2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61556118..61576615)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (60871312..60887777)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene Z30 small nucleolar RNA Neighboring gene uncharacterized LOC137495650 Neighboring gene peroxisomal biogenesis factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish. Lal P, et al. BMC Biol, 2018 Apr 25. PMID 29690872, Free PMC Article
    2. Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Wasilewska I, et al. Genes (Basel), 2019 Mar 18. PMID 30889933, Free PMC Article
    3. Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Gupta RK, et al. Int J Mol Sci, 2020 Aug 27. PMID 32867296, Free PMC Article
    4. Identification of Ca(2+) signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres. Tse MK, et al. Sci China Life Sci, 2018 Nov. PMID 29931586
    5. stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Wasilewska I, et al. Cells, 2020 May 21. PMID 32455839, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein orai-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166447.1 → NP_001159919.1  protein orai-2

      Status: PROVISIONAL

      Source sequence(s)
      AL935280
      UniProtKB/TrEMBL
      A0A8M1NVP7, F6P4G9
      Related
      ENSDARP00000121457.1, ENSDART00000131937.2
      Conserved Domains (1) summary
      pfam07856
      Location:49 → 241
      Orai-1; Mediator of CRAC channel activity

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      61556118..61576615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165570.5 → XP_005165627.1  protein orai-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCU4
      Conserved Domains (1) summary
      pfam07856
      Location:63 → 255
      Orai-1; Mediator of CRAC channel activity
    Nucleotide Protein
    Heading Accession and Version

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