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    zranb1a zinc finger, RAN-binding domain containing 1a [ Danio rerio (zebrafish) ]

    Gene ID: 334230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zranb1aprovided by ZNC
    Official Full Name
    zinc finger, RAN-binding domain containing 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100212-3
    See related
    Ensembl:ENSDARG00000060257 AllianceGenome:ZFIN:ZDB-GENE-100212-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi37b03; wu:fi37b03
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Acts upstream of or within brain development. Is expressed in female organism. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zranb1a in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47044787..47072244)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47104471..47125421)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene ornithine aminotransferase Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene ryanodine receptor 2a (cardiac)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
    2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: ubiquitin thioesterase ZRANB1; zinc finger, RAN-binding domain containing 1a
    XP_009305260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      47044787..47072244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306985.4 → XP_009305260.1  LOW QUALITY PROTEIN: ubiquitin thioesterase ZRANB1

      UniProtKB/TrEMBL
      A0A8M3BED9
      Related
      ENSDARP00000079149.6, ENSDART00000084714.6
      Conserved Domains (3) summary
      smart00547
      Location:7 → 29
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:8 → 27
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:419 → 567
      OTU; OTU-like cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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