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    tmem14ca transmembrane protein 14Ca [ Danio rerio (zebrafish) ]

    Gene ID: 751728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem14caprovided by ZNC
    Official Full Name
    transmembrane protein 14Caprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-156
    See related
    Ensembl:ENSDARG00000110836 AllianceGenome:ZFIN:ZDB-GENE-060825-156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem14c; zgc:153439
    Summary
    Acts upstream of or within heme biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. Is expressed in intermediate cell mass of mesoderm and ventral wall of dorsal aorta. Orthologous to several human genes including TMEM14C (transmembrane protein 14C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tmem14ca in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (8736493..8741837)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (8596089..8601452)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B3 Neighboring gene transcription factor AP-2 alpha Neighboring gene male germ cell-associated kinase Neighboring gene uncharacterized LOC110438349 Neighboring gene glial cells missing transcription factor 2 Neighboring gene synaptonemal complex protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
    2. Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Covassin L, et al. Dev Biol, 2006 Nov 15. PMID 16999953, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for functional heme biosynthesis in erythroid cells.
      Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153439

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 14C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045438.1 → NP_001038903.1  transmembrane protein 14C

      See identical proteins and their annotated locations for NP_001038903.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122294
      UniProtKB/Swiss-Prot
      Q0P436
      Related
      ENSDARP00000152761.1, ENSDART00000181904.1
      Conserved Domains (1) summary
      pfam03647
      Location:5 → 94
      Tmemb_14; Transmembrane proteins 14C

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      8736493..8741837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162574.5 → XP_005162631.3  transmembrane protein 14C isoform X1

    2. XM_005162575.5 → XP_005162632.1  transmembrane protein 14C isoform X2

      UniProtKB/TrEMBL
      A0A2R8QK55, A0A8M2B9G8
      Conserved Domains (1) summary
      pfam03647
      Location:5 → 94
      Tmemb_14; Transmembrane proteins 14C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P436.1 GenPept UniProtKB/Swiss-Prot:Q0P436

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