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    cadm2a cell adhesion molecule 2a [ Danio rerio (zebrafish) ]

    Gene ID: 793954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cadm2aprovided by ZNC
    Official Full Name
    cell adhesion molecule 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1614
    See related
    Ensembl:ENSDARG00000009930 AllianceGenome:ZFIN:ZDB-GENE-040426-1614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    igsf4d; zgc:66339
    Summary
    Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. Is expressed in immature eye; nervous system; and pancreatic system. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cadm2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (23215874..23909118, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (23242940..23939711, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene notchless homolog 1 (Drosophila) Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene si:ch73-122g19.1 Neighboring gene CD209 antigen-like protein A Neighboring gene zmp:0000000924 Neighboring gene C-type lectin domain family 4 member F-like Neighboring gene CD209 antigen-like protein D Neighboring gene asialoglycoprotein receptor 1-like Neighboring gene uncharacterized LOC101884413 Neighboring gene uncharacterized LOC103908728 Neighboring gene uncharacterized LOC137490385 Neighboring gene uncharacterized LOC137496587 Neighboring gene uncharacterized LOC100537962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Recursive splicing in long vertebrate genes. Sibley CR, et al. Nature, 2015 May 21. PMID 25970246, Free PMC Article
    2. Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system. Hunter PR, et al. J Comp Neurol, 2011 Aug 1. PMID 21456004
    3. Six cadm/SynCAM genes are expressed in the nervous system of developing zebrafish. Pietri T, et al. Dev Dyn, 2008 Jan. PMID 18095341, Free PMC Article
    4. Cadm4 restricts the production of cardiac outflow tract progenitor cells. Zeng XX, et al. Cell Rep, 2014 May 22. PMID 24813897, Free PMC Article
    5. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Gao X, et al. Cell Rep, 2015 Jul 28. PMID 26190107

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that cadm3 and cadm2a are expressed throughout the nervous system of larval stage zebrafish.
      Title: Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66339, MGC173997

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule 2a
    Names
    immunoglobulin superfamily, member 4d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200664.1 → NP_956958.1  cell adhesion molecule 2a precursor

      See identical proteins and their annotated locations for NP_956958.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057517
      UniProtKB/TrEMBL
      Q6PFK4
      Related
      ENSDARP00000113546.1, ENSDART00000135475.2
      Conserved Domains (5) summary
      smart00294
      Location:358 → 376
      4.1m; putative band 4.1 homologues' binding motif
      cd07701
      Location:41 → 135
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      smart00408
      Location:252 → 315
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:45 → 135
      IG_like; Immunoglobulin like
      cl11960
      Location:156 → 235
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      23215874..23909118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155264.5 → XP_005155321.1  cell adhesion molecule 2a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B1G4
      Related
      ENSDARP00000056368.6, ENSDART00000056369.7
      Conserved Domains (5) summary
      smart00294
      Location:380 → 398
      4.1m; putative band 4.1 homologues' binding motif
      cd07701
      Location:26 → 120
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      smart00408
      Location:237 → 300
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:30 → 120
      IG_like; Immunoglobulin like
      cl11960
      Location:141 → 220
      Ig; Immunoglobulin domain

    2. XM_005155263.5 → XP_005155320.1  cell adhesion molecule 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B1M0
      Conserved Domains (5) summary
      smart00294
      Location:395 → 413
      4.1m; putative band 4.1 homologues' binding motif
      cd07701
      Location:41 → 135
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      smart00408
      Location:252 → 315
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:45 → 135
      IG_like; Immunoglobulin like
      cl11960
      Location:156 → 235
      Ig; Immunoglobulin domain

    3. XM_021479207.2 → XP_021334882.1  cell adhesion molecule 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PTN6
      Conserved Domains (4) summary
      smart00294
      Location:389 → 407
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:246 → 309
      IGc2; Immunoglobulin C-2 Type
      cd07701
      Location:35 → 129
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cl11960
      Location:150 → 229
      Ig; Immunoglobulin domain

    4. XM_021479208.2 → XP_021334883.1  cell adhesion molecule 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q678
      Conserved Domains (4) summary
      smart00294
      Location:386 → 404
      4.1m; putative band 4.1 homologues' binding motif
      smart00408
      Location:243 → 306
      IGc2; Immunoglobulin C-2 Type
      cd07701
      Location:32 → 126
      Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
      cl11960
      Location:147 → 226
      Ig; Immunoglobulin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394784.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      902..174314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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