snx7 sorting nexin 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: snx7provided by ZNC
Official Full Name: sorting nexin 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-77
See related: Ensembl:ENSDARG00000105185 AllianceGenome:ZFIN:ZDB-GENE-040704-77
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92458
Summary: Enables cysteine-type endopeptidase activity. Acts upstream of or within apoptotic process; liver development; and negative regulation of apoptotic process. Predicted to be active in early endosome and phagophore assembly site. Is expressed in gut and liver. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (30227941..30275308, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (30221677..30269650, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX7 is a liver-enriched antiapoptotic protein that is indispensable for the survival of hepatoblasts during zebrafish early embryogenesis.
Title: An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sorting nexin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002229.2 → NP_001002229.2 sorting nexin-7

Status: VALIDATED

Source sequence(s)

BC074057, CU929325

UniProtKB/TrEMBL

A0A0R4IIY5, A0A8M1N046, Q6GMJ0

Related

ENSDARP00000133335.1, ENSDART00000168723.2

Conserved Domains (2) summary

cd07284
Location:80 → 195

PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7

cd07666
Location:179 → 421

BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

30227941..30275308 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162844.5 → XP_005162901.1 sorting nexin-7 isoform X1

UniProtKB/TrEMBL

A0A0R4IBS8, A0A8M2B9U9, Q6GMJ0

Related

ENSDARP00000131073.1, ENSDART00000164187.3

Conserved Domains (2) summary

cd07284
Location:80 → 195

PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7

cl12013
Location:179 → 455

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature