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    arhgap27l Rho GTPase activating protein 27, like [ Danio rerio (zebrafish) ]

    Gene ID: 566523, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgap27lprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 27, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120406-11
    See related
    Ensembl:ENSDARG00000061798 AllianceGenome:ZFIN:ZDB-GENE-120406-11
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See arhgap27l in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (22377307..22421932)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (22246665..22291384)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490552 Neighboring gene interferon phi 2 Neighboring gene interferon phi 1 Neighboring gene uncharacterized LOC110439080 Neighboring gene cytochrome C oxidase assembly factor 3b Neighboring gene WNK lysine deficient protein kinase 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Lisse TS, et al. Sci Rep, 2016 Feb 5. PMID 26846883, Free PMC Article
    2. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 15; rho GTPase-activating protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      22377307..22421932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689796.8 → XP_694888.4  rho GTPase-activating protein 27 isoform X1

      UniProtKB/TrEMBL
      A0A8N7T856, E7F1R9
      Related
      ENSDARP00000129871.1, ENSDART00000155597.2
      Conserved Domains (5) summary
      cd12069
      Location:15 → 71
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      cd04403
      Location:821 → 1006
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:633 → 744
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:632 → 745
      PH; PH domain
      pfam00397
      Location:394 → 422
      WW; WW domain

    2. XM_005171602.5 → XP_005171659.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      A0A2R8QDR5, A0A8M2BIZ8
      Related
      ENSDARP00000149989.1, ENSDART00000181506.1
      Conserved Domains (5) summary
      cd12069
      Location:15 → 71
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      cd04403
      Location:800 → 985
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:612 → 723
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:611 → 724
      PH; PH domain
      pfam00397
      Location:394 → 422
      WW; WW domain

    3. XM_017354750.3 → XP_017210239.1  rho GTPase-activating protein 15 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YWQ9
    Nucleotide Protein
    Heading Accession and Version

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