galns galactosamine (N-acetyl)-6-sulfatase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: galnsprovided by ZNC
Official Full Name: galactosamine (N-acetyl)-6-sulfataseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1152
See related: Ensembl:ENSDARG00000051853 AllianceGenome:ZFIN:ZDB-GENE-070112-1152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158385
Summary: Predicted to enable arylsulfatase activity. Predicted to be located in lysosome. Is expressed in brain. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (55543355..55633475, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (55241944..55332064, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetylgalactosamine-6-sulfatase activity	IEA Inferred from Electronic Annotation more info
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylgalactosamine-6-sulfatase

Names: galactosamine (N-acetyl)-6-sulfate sulfatase

NP_001074110.2

EC 3.1.6.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080641.2 → NP_001074110.2 N-acetylgalactosamine-6-sulfatase precursor

Status: VALIDATED

Source sequence(s)

BX248306, CR376726, CR388041, EH505880, EH532060

UniProtKB/TrEMBL

A0A8N7UYM1, F8W261

Related

ENSDARP00000124843.1, ENSDART00000149478.3

Conserved Domains (2) summary

COG3119
Location:18 → 475

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16157
Location:22 → 486

GALNS; galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)