ptpn4a protein tyrosine phosphatase non-receptor type 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpn4aprovided by ZNC
Official Full Name: protein tyrosine phosphatase non-receptor type 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-449
See related: Ensembl:ENSDARG00000000631 AllianceGenome:ZFIN:ZDB-GENE-030616-449
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptpn4; fa16h07; wu:fa16h07; si:dz37o5.1; si:busm1-37o5.1
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in developmental process. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (28940687..29029775, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (29129953..29219092, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 4

Names: protein tyrosine phosphatase non-receptor type 4; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

NP_001007201.1

EC 3.1.3.48

XP_068079424.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007200.1 → NP_001007201.1 tyrosine-protein phosphatase non-receptor type 4

See identical proteins and their annotated locations for NP_001007201.1

Status: PROVISIONAL

Source sequence(s)

AL672097

UniProtKB/TrEMBL

A0A8M1N2S5, Q8JFS7

Related

ENSDARP00000152804.1, ENSDART00000183391.1

Conserved Domains (8) summary

smart00194
Location:653 → 903

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:30 → 222

B41; Band 4.1 homologues

cd00047
Location:680 → 902

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:513 → 600

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 310

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14473
Location:122 → 214

FERM_B-lobe; FERM domain B-lobe

pfam08736
Location:325 → 364

FA; FERM adjacent (FA)

pfam09379
Location:33 → 97

FERM_N; FERM N-terminal domain