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    angptl3 angiopoietin-like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 114421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    angptl3provided by ZNC
    Official Full Name
    angiopoietin-like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010817-3
    See related
    Ensembl:ENSDARG00000044365 AllianceGenome:ZFIN:ZDB-GENE-010817-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb60e11; fb66h02; wu:fb60e11; wu:fb66h02; zgc:111943
    Summary
    Predicted to enable phospholipase inhibitor activity. Acts upstream of or within hepatocyte proliferation and lipid metabolic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in liver; liver primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See angptl3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (32344673..32349151, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (32357759..32362237, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495883 Neighboring gene autophagy related 4C, cysteine peptidase Neighboring gene dedicator of cytokinesis 7 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene KN motif and ankyrin repeat domains 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation and expression analysis of three zebrafish angiopoietin genes. Pham VN, et al. Dev Dyn, 2001 Aug. PMID 11500985
    2. Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish. Lee SH, et al. Biochem Biophys Res Commun, 2014 Apr 18. PMID 24685482
    3. Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I, et al. Elife, 2022 Feb 8. PMID 35133277, Free PMC Article
    4. Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish. Atienzar-Aroca R, et al. Int J Mol Sci, 2022 Sep 1. PMID 36077382, Free PMC Article
    5. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Wang Y, et al. Genome Biol Evol, 2015 Oct 9. PMID 26454018, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Angptl3 decreases liver size in developing zebrafish.
      Title: Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phospholipase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131818.3 → NP_571893.2  angiopoietin-related protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      BX936431, EH447322
      UniProtKB/TrEMBL
      A0A8N7UZN6, F1QYL5
      Related
      ENSDARP00000117939.1, ENSDART00000140004.3
      Conserved Domains (2) summary
      cd00087
      Location:248 → 461
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl25732
      Location:111 → 209
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      32344673..32349151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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