fam53b family with sequence similarity 53 member B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fam53bprovided by ZNC
Official Full Name: family with sequence similarity 53 member Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2495
See related: Ensembl:ENSDARG00000016156 AllianceGenome:ZFIN:ZDB-GENE-040426-2495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55329; zgc:77156; wu:fo86c04
Summary: Acts upstream of or within several processes, including axon extension; fin regeneration; and positive regulation of canonical Wnt signaling pathway. Located in nucleus. Is expressed in Rohon-Beard neurons; head; regenerating fin; trigeminal sensory neurons; and trunk. Orthologous to human FAM53B (family with sequence similarity 53 member B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (46883785..46937956)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (46867593..46921772)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both Smp and beta-catenin function in a common molecular pathway with cx43 to influence both evx1 expression and joint location.
Title: Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43.
smp is required in fin regeneration through control of cell proliferation, the regulation of specific genes and proper bone patterning.
Title: Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration.

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General gene information

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Markers

fj93e03.x1 (e-PCR)
- UniSTS:200368

fj24c07.y1 (e-PCR)
- UniSTS:198850

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein FAM53B

Names: protein simplet; simplet; smp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007187.1 → NP_001007188.1 protein FAM53B

See identical proteins and their annotated locations for NP_001007188.1

Status: PROVISIONAL

Source sequence(s)

BC066405

UniProtKB/Swiss-Prot

F1QN48, Q6NYZ5, Q7ZUQ7

Related

ENSDARP00000020465.6, ENSDART00000008312.8

Conserved Domains (1) summary

pfam15242
Location:5 → 267

FAM53; Family of FAM53

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

46883785..46937956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156440.5 → XP_005156497.1 protein FAM53B isoform X1

UniProtKB/Swiss-Prot

F1QN48, Q6NYZ5, Q7ZUQ7

UniProtKB/TrEMBL

A0A8M2B2I1

Conserved Domains (1) summary

pfam15242
Location:5 → 266

FAM53; Family of FAM53