caspa caspase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: caspaprovided by ZNC
Official Full Name: caspase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-3
See related: Ensembl:ENSDARG00000008165 AllianceGenome:ZFIN:ZDB-GENE-000616-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: casp1; caspy; fa93b02; wu:fa93b02; zgc:109869
Summary: Enables Pyrin domain binding activity and cysteine-type endopeptidase activity. Involved in self proteolysis. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; innate immune response; and pyroptotic inflammatory response. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; hematopoietic system; integument; and male organism. Orthologous to several human genes including CASP4 (caspase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (41993556..42004481, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (42043524..42054449, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The fish caspase-1 homolog Caspy, but not the caspase-4/11 homolog Caspy2, interacts with zebrafish ASC through homotypic PYD-PYD interactions, which differ from those in mammals.
Title: Functional and structural characterization of zebrafish ASC.
role in pharyngeal arch development
Title: Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Pyrin domain binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyroptotic inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in self proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP1 inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of NLRP1 inflammasome complex	IPI Inferred from Physical Interaction more info	PubMed
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of canonical inflammasome complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caspase a

Names: caspase 1

NP_571580.1

EC 3.4.22.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131505.2 → NP_571580.1 caspase a

See identical proteins and their annotated locations for NP_571580.1

Status: PROVISIONAL

Source sequence(s)

BC095022

UniProtKB/Swiss-Prot

A0A2U9DQN4, Q9I9L7

Related

ENSDARP00000034228.7, ENSDART00000034544.9

Conserved Domains (2) summary

cd00032
Location:134 → 380

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:6 → 85

DD; Death Domain Superfamily of protein-protein interaction domains