psat1 phosphoserine aminotransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psat1provided by ZNC
Official Full Name: phosphoserine aminotransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5723
See related: Ensembl:ENSDARG00000016733 AllianceGenome:ZFIN:ZDB-GENE-030131-5723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi15b02; zgc:55738; zgc:77622; wu:fi15b02
Summary: Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process. Predicted to be active in cytoplasm. Is expressed in immature eye; myotome; nervous system; and pigment cell. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (69486341..69499615, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68713693..68727222, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-serine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphoserine aminotransferase

NP_956113.1

EC 2.6.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199819.2 → NP_956113.1 phosphoserine aminotransferase isoform 1

See identical proteins and their annotated locations for NP_956113.1

Status: VALIDATED

Source sequence(s)

EH432914, EH458920, LO017803

UniProtKB/TrEMBL

A0A8M1PA76, Q803I7

Related

ENSDARP00000147073.1, ENSDART00000180293.1

Conserved Domains (2) summary

cd00611
Location:7 → 365

PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...

COG1932
Location:1 → 367

SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]