ihhb Indian hedgehog signaling molecule b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ihhbprovided by ZNC
Official Full Name: Indian hedgehog signaling molecule bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-135
See related: Ensembl:ENSDARG00000058815 AllianceGenome:ZFIN:ZDB-GENE-980526-135
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IHH; ehh; zgc:113262
Summary: Predicted to enable several functions, including cholesterol-protein transferase activity; patched binding activity; and very-low-density lipoprotein particle binding activity. Acts upstream of or within oligodendrocyte differentiation; regulation of oligodendrocyte progenitor proliferation; and striated muscle cell development. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and extracellular region. Predicted to be active in extracellular space. Is expressed in axis; central nervous system; cranium; gut; and notochord. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (7059999..7081863, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (6902830..6925478, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (Hh) signaling during eye development.
Title: Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis.
data from the present study suggested a novel mechanism, mediated by Ihhb, for the sequential generation of motor neurons and oligodendrocytes from precursors in the ventral spinal cord of zebrafish embryos
Title: Indian hedgehog B function is required for the specification of oligodendrocyte progenitor cells in the zebrafish CNS.
Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning
Title: Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling.
Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.
Title: Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

EHH (e-PCR)
- UniSTS:205328

ehh (e-PCR), detects polymorphism
- UniSTS:238250

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein autoprocessing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in self proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within striated muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: indian hedgehog B protein

Names: Indian hedgehog homolog b; echidna hedgehog protein; hh[b]; hhb

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131088.1 → NP_571163.1 indian hedgehog B protein precursor

See identical proteins and their annotated locations for NP_571163.1

Status: PROVISIONAL

Source sequence(s)

Y08426

UniProtKB/Swiss-Prot

Q98862

Related

ENSDARP00000076199.4, ENSDART00000081760.5

Conserved Domains (3) summary

cd00081
Location:198 → 348

Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

pfam01079
Location:187 → 398

Hint; Hint module

pfam01085
Location:39 → 184

HH_signal; Hedgehog amino-terminal signalling domain