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    syt1a synaptotagmin Ia [ Danio rerio (zebrafish) ]

    Gene ID: 436736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syt1aprovided by ZNC
    Official Full Name
    synaptotagmin Iaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-165
    See related
    Ensembl:ENSDARG00000030614 AllianceGenome:ZFIN:ZDB-GENE-040718-165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    syt1; zgc:92899; wu:fj41c01; wu:fk56d05
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to be located in chromaffin granule membrane and synapse. Predicted to be active in axon; plasma membrane; and secretory vesicle. Is expressed in brain and visual system. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See syt1a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (21040603..21315408)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (21319537..21594424)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491546 Neighboring gene uncharacterized LOC101884898 Neighboring gene uncharacterized LOC137491545 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene protein phosphatase 1, regulatory subunit 12A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. Fontenas L, et al. PLoS Genet, 2016 Nov. PMID 27902705, Free PMC Article
    2. Characterization of Hspb8 in Zebrafish. Dubińska-Magiera M, et al. Cells, 2020 Jun 26. PMID 32604890, Free PMC Article
    3. Acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2018 May 21. PMID 29784925, Free PMC Article
    4. Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Haridevamuthu B, et al. Brain Res, 2022 Aug 1. PMID 35550141
    5. Modelling acrylamide acute neurotoxicity in zebrafish larvae. Prats E, et al. Sci Rep, 2017 Oct 24. PMID 29066856, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-1a
    Names
    synaptotagmin I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327829.1 → NP_001314758.1  synaptotagmin-1a

      Status: VALIDATED

      Source sequence(s)
      BX511172, BX511298, BX537146
      UniProtKB/TrEMBL
      A0A8M2BC70, Q5TZ27
      Related
      ENSDARP00000141860.1, ENSDART00000169764.2
      Conserved Domains (2) summary
      cd08385
      Location:139 → 261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270 → 405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      21040603..21315408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354995.3 → XP_017210484.1  synaptotagmin-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC70, Q5TZ27
      Conserved Domains (2) summary
      cd08385
      Location:139 → 261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270 → 405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    2. XM_009300373.4 → XP_009298648.1  synaptotagmin-1a isoform X2

      See identical proteins and their annotated locations for XP_009298648.1

      UniProtKB/TrEMBL
      A0A8M2BC44
      Conserved Domains (2) summary
      cd08385
      Location:136 → 258
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:267 → 402
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    3. XM_017354996.3 → XP_017210485.1  synaptotagmin-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC70, Q5TZ27
      Conserved Domains (2) summary
      cd08385
      Location:139 → 261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270 → 405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    4. XM_005164872.5 → XP_005164929.1  synaptotagmin-1a isoform X1

      See identical proteins and their annotated locations for XP_005164929.1

      UniProtKB/TrEMBL
      A0A8M2BC70, Q5TZ27
      Related
      ENSDARP00000041860.4, ENSDART00000041861.5
      Conserved Domains (2) summary
      cd08385
      Location:139 → 261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270 → 405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    5. XM_005164874.5 → XP_005164931.1  synaptotagmin-1a isoform X2

      See identical proteins and their annotated locations for XP_005164931.1

      UniProtKB/TrEMBL
      A0A8M2BC44
      Conserved Domains (2) summary
      cd08385
      Location:136 → 258
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:267 → 402
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002463.1: Suppressed sequence

      Description
      NM_001002463.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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