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    pak2b p21 protein (Cdc42/Rac)-activated kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 325034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pak2bprovided by ZNC
    Official Full Name
    p21 protein (Cdc42/Rac)-activated kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3759
    See related
    Ensembl:ENSDARG00000018476 AllianceGenome:ZFIN:ZDB-GENE-030131-3759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc52b03; zgc:113857; CH73-159L23.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in axial vasculature; endoderm; and nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pak2b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (2897170..2929156, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (2880903..2912890, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909515 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene centrosomal protein 19 Neighboring gene inhibitor of growth family, member 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Liu J, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17573532, Free PMC Article
    2. Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Kamstra JH, et al. Sci Rep, 2018 Oct 18. PMID 30337673, Free PMC Article
    3. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Buchner DA, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17715297, Free PMC Article
    4. Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Kovács R, et al. Water Res, 2015 Jun 15. PMID 25889180
    5. Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Peng X, et al. J Mol Cell Biol, 2021 Apr 10. PMID 33582796, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113857

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 2b
    Names
    p21 (CDKN1A)-activated kinase 2b
    NP_001020627.1
    XP_005170417.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025456.1 → NP_001020627.1  serine/threonine-protein kinase PAK 2b

      See identical proteins and their annotated locations for NP_001020627.1

      Status: PROVISIONAL

      Source sequence(s)
      BC096967
      UniProtKB/TrEMBL
      Q4V9B9
      Related
      ENSDARP00000046677.6, ENSDART00000046678.8
      Conserved Domains (3) summary
      cd06655
      Location:244 → 539
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:264 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74 → 129
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      2897170..2929156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170360.5 → XP_005170417.1  serine/threonine-protein kinase PAK 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BI44
      Related
      ENSDARP00000143950.2, ENSDART00000178290.2
      Conserved Domains (3) summary
      cd06655
      Location:225 → 520
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:245 → 496
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:57 → 112
      PBD; P21-Rho-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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