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    mafaa MAF bZIP transcription factor Aa [ Danio rerio (zebrafish) ]

    Gene ID: 100000492, updated on 9-Dec-2024

    Summary

    Official Symbol
    mafaaprovided by ZNC
    Official Full Name
    MAF bZIP transcription factor Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010605-3
    See related
    Ensembl:ENSDARG00000044155 AllianceGenome:ZFIN:ZDB-GENE-010605-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mafa; mafl; SMaf1
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in myotome; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mafaa in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (32699363..32703518, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (32714673..32718828, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 4 Neighboring gene uncharacterized LOC137495884 Neighboring gene zinc finger CCCH-type containing 3 Neighboring gene cylindromatosis (turban tumor syndrome), like

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    transcription factor MafAa
    Names
    Transcription factor MafA
    somite Maf1
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L
    v-maf musculoaponeurotic fibrosarcoma oncogene homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082940.2 → NP_001076409.1  transcription factor MafAa

      See identical proteins and their annotated locations for NP_001076409.1

      Status: VALIDATED

      Source sequence(s)
      CU694370, EH441535, EH467419
      UniProtKB/Swiss-Prot
      A3KMR8, Q98UK3
      UniProtKB/TrEMBL
      B3DGB3
      Related
      ENSDARP00000064832.4, ENSDART00000064833.5
      Conserved Domains (2) summary
      cd14718
      Location:218 → 287
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:106 → 139
      Maf_N; Maf N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      32699363..32703518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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