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    mkrn1 makorin, ring finger protein, 1 [ Danio rerio (zebrafish) ]

    Gene ID: 170782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mkrn1provided by ZNC
    Official Full Name
    makorin, ring finger protein, 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020213-1
    See related
    Ensembl:ENSDARG00000041665 AllianceGenome:ZFIN:ZDB-GENE-020213-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fl25h08; wu:fl25h08; zgc:110403
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within protein polyubiquitination. Is expressed in several structures, including brain; eye; gonad; integument; and liver. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mkrn1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12292285..12307039)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12293436..12308190)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178Bb Neighboring gene si:ch211-9f20.4 Neighboring gene CCR4-NOT transcription complex, subunit 4b Neighboring gene transmembrane protein 121B Neighboring gene interleukin 17 receptor A1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene. Gray TA, et al. Genomics, 2001 Oct. PMID 11597136
    2. The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. Böhne A, et al. BMC Genomics, 2010 Dec 20. PMID 21172006, Free PMC Article
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase makorin-1
    Names
    RING-type E3 ubiquitin transferase makorin-1
    NP_694510.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152978.1 → NP_694510.1  probable E3 ubiquitin-protein ligase makorin-1

      See identical proteins and their annotated locations for NP_694510.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095243
      UniProtKB/Swiss-Prot
      Q1L8F6, Q4VBT5, Q9DFG7
      UniProtKB/TrEMBL
      B2GQH3
      Related
      ENSDARP00000061069.6, ENSDART00000061070.8
      Conserved Domains (5) summary
      smart00356
      Location:18 → 44
      ZnF_C3H1; zinc finger
      PHA03096
      Location:176 → 325
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:235 → 290
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam15815
      Location:357 → 437
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam16131
      Location:52 → 84
      Torus; Torus domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      12292285..12307039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VBT5.1 GenPept UniProtKB/Swiss-Prot:Q4VBT5

    Gene LinkOut

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