SRPK3 SRSF protein kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRPK3provided by HGNC
Official Full Name: SRSF protein kinase 3provided by HGNC
Primary source: HGNC:HGNC:11402
See related: Ensembl:ENSG00000184343 MIM:301002; AllianceGenome:HGNC:11402
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MSSK1; STK23; MSSK-1; XLID114
Summary: This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression: Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq28

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (153781041..153785730)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (152054705..152059393)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (153046496..153051185)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRPK3 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
Alternative splicing of the alpha-exon of MEF2C regulates myogenesis. Loss of SRPK3 in rhabdomyosarcoma cells inhibits this splicing and blocks differentiation.
Title: Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of SRSF protein kinase 3 (SRPK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92840 (e-PCR)
- UniSTS:84482

RH92620 (e-PCR)
- UniSTS:91197

RH12600 (e-PCR)
- UniSTS:22155

A004O03 (e-PCR)
- UniSTS:67783

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SRSF protein kinase 3

Names: SFRS protein kinase 3; SR-protein-specific kinase 3; muscle-specific serine kinase 1; serine arginine rich protein-specific kinase 3; serine/threonine kinase 23; serine/threonine-protein kinase 23; serine/threonine-protein kinase SRPK3

NP_001164231.1

EC 2.7.11.1

NP_001164232.1

EC 2.7.11.1

NP_055185.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016329.1 RefSeqGene

Range

5041..9730

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170760.2 → NP_001164231.1 SRSF protein kinase 3 isoform 2

See identical proteins and their annotated locations for NP_001164231.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.

Source sequence(s)

BC117124, U52111

Consensus CDS

CCDS55538.1

UniProtKB/TrEMBL

A8MPY5

Related

ENSP00000359122.1, ENST00000370104.5

Conserved Domains (1) summary

cd14218
Location:68 → 564

STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3
NM_001170761.2 → NP_001164232.1 SRSF protein kinase 3 isoform 3

See identical proteins and their annotated locations for NP_001164232.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.

Source sequence(s)

AF027406, U52111

Consensus CDS

CCDS55537.1

UniProtKB/TrEMBL

A8MPY5

Related

ENSP00000377376.3, ENST00000393786.7

Conserved Domains (2) summary

smart00220
Location:79 → 531

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14218
Location:68 → 531

STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3
NM_014370.4 → NP_055185.2 SRSF protein kinase 3 isoform 1

See identical proteins and their annotated locations for NP_055185.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC092416, U52111

Consensus CDS

CCDS35441.1

UniProtKB/Swiss-Prot

Q13583, Q4F970, Q562F5, Q9UM62, Q9UPE1

UniProtKB/TrEMBL

A8MPY5

Related

ENSP00000359119.3, ENST00000370101.8

Conserved Domains (2) summary

smart00220
Location:79 → 565

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14218
Location:68 → 565

STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3