IL36B interleukin 36 beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL36Bprovided by HGNC
Official Full Name: interleukin 36 betaprovided by HGNC
Primary source: HGNC:HGNC:15564
See related: Ensembl:ENSG00000136696 MIM:605508; AllianceGenome:HGNC:15564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression: Biased expression in skin (RPKM 1.1) and esophagus (RPKM 0.5) See more
Orthologs: mouse all
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Genomic context

Location:: 2q14.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (113022089..113052867, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (113448613..113479393, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (113779666..113810444, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
Title: Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
Increased Interleukin-36beta Expression Promotes Angiogenesis in Japanese Atopic Dermatitis.
Title: Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis.
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
Title: IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic.
IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
Title: IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases.
Title: Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases.
IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?
Title: IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?
these findings suggest that IL-36beta could induce cell cycle arrest at S phase, inhibit keratin 10 and involucrin expressions and promote inflammatory activity in HaCaT cell lines.
Title: IL-36β Promotes Inflammatory Activity and Inhibits Differentiation of Keratinocytes In Vitro.
IL-36-mediated IL-6 and CXCL8 production in human lung fibroblasts and bronchial epithelial cells may be involved in pulmonary inflammation especially caused by bacterial or viral infections.
Title: IL-36 induces cytokine IL-6 and chemokine CXCL8 expression in human lung tissue cells: Implications for pulmonary inflammatory responses.
With a focus on the skin as a target for microbial and viral invasion, the current knowledge of IL-36: IL-36alpha, IL-36beta and IL-36gamma, functions is reviewed. One physiological function of the IL-36smay be to counteract microbial immune evasion. [Review]
Title: Interleukin-36 cytokines may overcome microbial immune evasion strategies that inhibit interleukin-1 family signaling.
IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483191

IL1F8_2206 (e-PCR)
- UniSTS:280781

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-36 beta

Names: FIL1 eta; IL-1 eta; IL-1F8 (FIL1-eta); Interleukin-1 Superfamily e; family of interleukin 1-eta; interleukin 1 family, member 8 (eta); interleukin-1 eta; interleukin-1 family member 8; interleukin-1 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014438.5 → NP_055253.2 interleukin-36 beta isoform 1

See identical proteins and their annotated locations for NP_055253.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes a longer isoform (1).

Source sequence(s)

AC016724, AF200494

Consensus CDS

CCDS2109.1

UniProtKB/Swiss-Prot

Q3MIH0, Q53SR6, Q7RTZ7, Q9NZH7, Q9UHA5

Related

ENSP00000259213.4, ENST00000259213.9

Conserved Domains (1) summary

cl00094
Location:12 → 87

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173178.3 → NP_775270.1 interleukin-36 beta isoform 2

See identical proteins and their annotated locations for NP_775270.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' region, which includes a part of the coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AC016724, AF201833, CA441070

Consensus CDS

CCDS2110.1

UniProtKB/Swiss-Prot

Q9NZH7

Related

ENSP00000328420.2, ENST00000327407.2

Conserved Domains (1) summary

cl00094
Location:12 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

113022089..113052867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510962.1 → XP_011509264.1 interleukin-36 beta isoform X1

See identical proteins and their annotated locations for XP_011509264.1

UniProtKB/Swiss-Prot

Q9NZH7

Conserved Domains (1) summary

cl00094
Location:12 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).