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    DENND2B DENN domain containing 2B [ Homo sapiens (human) ]

    Gene ID: 6764, updated on 10-Dec-2024

    Summary

    Official Symbol
    DENND2Bprovided by HGNC
    Official Full Name
    DENN domain containing 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:11350
    See related
    Ensembl:ENSG00000166444 MIM:140750; AllianceGenome:HGNC:11350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST5; HTS1; p126
    Summary
    This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 30.7), testis (RPKM 16.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DENND2B in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8693352..8910951, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8775106..8995121, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8714899..8932498, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4390 Neighboring gene Sharpr-MPRA regulatory region 3983 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8719729-8720516 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8720517-8721302 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8723665-8724450 Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8731697-8732198 Neighboring gene uncharacterized LOC107984308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8780393-8780893 Neighboring gene DENND2B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8827143-8827644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8827645-8828144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8850107-8850606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8853387-8854188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8854189-8854989 Neighboring gene RNA, 5S ribosomal pseudogene 330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8884480-8884980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8884981-8885481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8946857-8947641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8947642-8948425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8954113-8954951 Neighboring gene chromosome 11 open reading frame 16 Neighboring gene A-kinase interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4397 Neighboring gene achaete-scute family bHLH transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1252 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • MGC33090

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cell cortex  
    located_in plasma membrane  
    located_in recycling endosome  

    General protein information

    Preferred Names
    DENN domain-containing protein 2B
    Names
    DENN/MADD domain containing 2B
    heLa tumor suppression 1
    suppression of tumorigenicity 5 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029450.1 RefSeqGene

      Range
      105278..222600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001376495.1 → NP_001363424.1  DENN domain-containing protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7791.1
      UniProtKB/Swiss-Prot
      B2R6X7, B3KXQ6, P78523, P78524, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
      Conserved Domains (4) summary
      smart00801
      Location:1023 → 1089
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:697 → 784
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:791 → 972
      DENN; DENN (AEX-3) domain
    2. NM_001376496.1 → NP_001363425.1  DENN domain-containing protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7791.1
      UniProtKB/Swiss-Prot
      B2R6X7, B3KXQ6, P78523, P78524, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
      Conserved Domains (4) summary
      smart00801
      Location:1023 → 1089
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:697 → 784
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:791 → 972
      DENN; DENN (AEX-3) domain
    3. NM_001376497.1 → NP_001363426.1  DENN domain-containing protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7791.1
      UniProtKB/Swiss-Prot
      B2R6X7, B3KXQ6, P78523, P78524, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
      Conserved Domains (4) summary
      smart00801
      Location:1023 → 1089
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:697 → 784
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:791 → 972
      DENN; DENN (AEX-3) domain
    4. NM_001376498.1 → NP_001363427.1  DENN domain-containing protein 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Conserved Domains (3) summary
      smart00801
      Location:854 → 920
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:622 → 803
      DENN; DENN (AEX-3) domain
    5. NM_001376499.1 → NP_001363428.1  DENN domain-containing protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Conserved Domains (3) summary
      smart00801
      Location:843 → 909
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:517 → 604
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:611 → 792
      DENN; DENN (AEX-3) domain
    6. NM_001376500.1 → NP_001363429.1  DENN domain-containing protein 2B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Conserved Domains (3) summary
      smart00801
      Location:796 → 862
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:470 → 557
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:564 → 745
      DENN; DENN (AEX-3) domain
    7. NM_001376501.1 → NP_001363430.1  DENN domain-containing protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7792.1
      UniProtKB/TrEMBL
      B4DDL8
      Related
      ENSP00000436802.1, ENST00000530438.5
      Conserved Domains (3) summary
      smart00801
      Location:603 → 669
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:277 → 364
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:371 → 552
      DENN; DENN (AEX-3) domain
    8. NM_001376502.1 → NP_001363431.1  DENN domain-containing protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7792.1
      UniProtKB/TrEMBL
      B4DDL8
      Conserved Domains (3) summary
      smart00801
      Location:603 → 669
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:277 → 364
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:371 → 552
      DENN; DENN (AEX-3) domain
    9. NM_001376503.1 → NP_001363432.1  DENN domain-containing protein 2B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      UniProtKB/TrEMBL
      B4DDL8
      Conserved Domains (3) summary
      smart00801
      Location:543 → 609
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:311 → 492
      DENN; DENN (AEX-3) domain
      cl04085
      Location:277 → 314
      uDENN; uDENN domain
    10. NM_001376504.1 → NP_001363433.1  DENN domain-containing protein 2B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      UniProtKB/TrEMBL
      B4DDL8
      Conserved Domains (3) summary
      smart00801
      Location:531 → 597
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:205 → 292
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:299 → 480
      DENN; DENN (AEX-3) domain
    11. NM_001376505.1 → NP_001363434.1  DENN domain-containing protein 2B isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS91434.1
      UniProtKB/TrEMBL
      B4DDL8
      Related
      ENSP00000432887.1, ENST00000530991.5
      Conserved Domains (3) summary
      smart00801
      Location:495 → 561
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:169 → 256
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:263 → 444
      DENN; DENN (AEX-3) domain
    12. NM_001376506.1 → NP_001363435.1  DENN domain-containing protein 2B isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS91434.1
      UniProtKB/TrEMBL
      B4DDL8
      Conserved Domains (3) summary
      smart00801
      Location:495 → 561
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:169 → 256
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:263 → 444
      DENN; DENN (AEX-3) domain
    13. NM_005418.4 → NP_005409.3  DENN domain-containing protein 2B isoform 1

      See identical proteins and their annotated locations for NP_005409.3

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7791.1
      UniProtKB/Swiss-Prot
      B2R6X7, B3KXQ6, P78523, P78524, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
      Related
      ENSP00000433528.1, ENST00000534127.5
      Conserved Domains (4) summary
      smart00801
      Location:1023 → 1089
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:697 → 784
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:791 → 972
      DENN; DENN (AEX-3) domain
    14. NM_139157.3 → NP_631896.1  DENN domain-containing protein 2B isoform 2

      See identical proteins and their annotated locations for NP_631896.1

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
      Consensus CDS
      CCDS7792.1
      UniProtKB/TrEMBL
      B4DDL8
      Conserved Domains (3) summary
      smart00801
      Location:603 → 669
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:277 → 364
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:371 → 552
      DENN; DENN (AEX-3) domain
    15. NM_213618.2 → NP_998783.1  DENN domain-containing protein 2B isoform 1

      See identical proteins and their annotated locations for NP_998783.1

      Status: REVIEWED

      Source sequence(s)
      BC036655, BX647431, U15131, U15780
      Consensus CDS
      CCDS7791.1
      UniProtKB/Swiss-Prot
      B2R6X7, B3KXQ6, P78523, P78524, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6
      Related
      ENSP00000319678.6, ENST00000313726.11
      Conserved Domains (4) summary
      smart00801
      Location:1023 → 1089
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:697 → 784
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:46 → 411
      PHA03247; large tegument protein UL36; Provisional
      pfam02141
      Location:791 → 972
      DENN; DENN (AEX-3) domain

    RNA

    1. NR_164814.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    2. NR_164815.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    3. NR_164816.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    4. NR_164817.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    5. NR_164818.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    6. NR_164819.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    7. NR_164820.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    8. NR_164821.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053
    9. NR_164822.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC026894, AC091053

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      8693352..8910951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8775106..8995121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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