TMT1B thiol methyltransferase 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMT1Bprovided by HGNC
Official Full Name: thiol methyltransferase 1Bprovided by HGNC
Primary source: HGNC:HGNC:28276
See related: Ensembl:ENSG00000170439 AllianceGenome:HGNC:28276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALDI; METTL7B
Summary: Enables thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver (RPKM 58.0), duodenum (RPKM 25.7) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (55681736..55684611)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (55648368..55651240)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56075520..56078395)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors.
Title: The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors.
lncRNA PDCD4-AS1 Promotes the Progression of Glioma by Regulating miR-30b-3p/METTL7B Signaling.
Title: lncRNA PDCD4-AS1 Promotes the Progression of Glioma by Regulating miR-30b-3p/METTL7B Signaling.
Prognostic Potential of METTL7B in Glioma.
Title: Prognostic Potential of METTL7B in Glioma.
circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis.
Title: circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis.
Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.
Title: Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.
Potent necrosis effect of methanethiol mediated by METTL7B enzyme bioactivation mechanism in 16HBE cell.
Title: Potent necrosis effect of methanethiol mediated by METTL7B enzyme bioactivation mechanism in 16HBE cell.
METTL7B contributes to the malignant progression of glioblastoma by inhibiting EGR1 expression.
Title: METTL7B contributes to the malignant progression of glioblastoma by inhibiting EGR1 expression.
Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma.
Title: Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma.
Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril.
Title: Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril.
Low Molecular Pectin Inhibited the Lipid Accumulation by Upregulation of METTL7B.
Title: Low Molecular Pectin Inhibited the Lipid Accumulation by Upregulation of METTL7B.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X74295 (e-PCR)
- UniSTS:48931

SHGC-82400 (e-PCR)
- UniSTS:104543

WI-16635 (e-PCR)
- UniSTS:627

RH11299 (e-PCR)
- UniSTS:21626

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thiol S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiol S-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiol S-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thiol S-methyltransferase TMT1B

Names: associated with lipid droplets 1; methyltransferase like 7B; methyltransferase-like protein 7B; thiol S-methyltransferase METTL7B

NP_689850.2

EC 2.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.