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    MOB3C MOB kinase activator 3C [ Homo sapiens (human) ]

    Gene ID: 148932, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MOB3Cprovided by HGNC
    Official Full Name
    MOB kinase activator 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:29800
    See related
    Ensembl:ENSG00000142961 MIM:620804; AllianceGenome:HGNC:29800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOB1E; MOBKL2C
    Summary
    The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 4.4), spleen (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOB3C in Genome Data Viewer
    Location:
    1p33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46607719..46616811, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46484946..46494037, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47073391..47082483, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MKNK1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013004-47013504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013505-47014005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47015442-47016081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47021539-47022040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47022041-47022540 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47024335-47024504 Neighboring gene kinocilin Neighboring gene MAPK interacting serine/threonine kinase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:47069254-47069754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47078933-47079556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 849 Neighboring gene uncharacterized LOC105378697 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47131482-47132011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47132012-47132540 Neighboring gene neudesin neurotrophic factor pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of human homologs of yeast MOB1. Chow A, et al. Int J Cancer, 2010 May 1. PMID 19739119
    2. Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex. Elkholi IE, et al. J Biol Chem, 2023 Sep. PMID 37536630, Free PMC Article
    3. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article
    4. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, et al. Biochem J, 2016 Oct 15. PMID 27503909, Free PMC Article
    5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3C
    Names
    MOB1, Mps One Binder kinase activator-like 2C
    mob1 homolog 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027514.1 RefSeqGene

      Range
      5081..14173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_145279.5 → NP_660322.3  MOB kinase activator 3C

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL136373
      Consensus CDS
      CCDS540.1
      UniProtKB/Swiss-Prot
      D3DQ22, Q0VA98, Q5TC10, Q5TC11, Q70IA8, Q8NAZ2, Q8NF28
      UniProtKB/TrEMBL
      X6R3L3
      Related
      ENSP00000271139.9, ENST00000271139.13
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    2. NM_201403.3 → NP_958805.1  MOB kinase activator 3C

      See identical proteins and their annotated locations for NP_958805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' UTR exon, compared to variant 1, that results in the use of a downstream start codon. The encoded isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL136373
      Consensus CDS
      CCDS540.1
      UniProtKB/Swiss-Prot
      D3DQ22, Q0VA98, Q5TC10, Q5TC11, Q70IA8, Q8NAZ2, Q8NF28
      UniProtKB/TrEMBL
      X6R3L3
      Related
      ENSP00000315113.3, ENST00000319928.9
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46607719..46616811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46484946..46494037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70IA8.1 GenPept UniProtKB/Swiss-Prot:Q70IA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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