let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-23
Official Full Name: Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
Primary source: WormBase:WBGene00002299
Locus tag: CELE_ZK1067.1
See related: AllianceGenome:WB:WBGene00002299
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables epidermal growth factor receptor activity; lipid binding activity; and molecular function activator activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Is expressed in several structures, including apoptotic cell; epithelial cell; head; somatic nervous system; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-23 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 20

Sequence:: Chromosome: II; NC_003280.10 (9197512..9207213)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.
Title: LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.
An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 basolateral localization and signaling during C. elegans vulva induction.
Title: An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
ERM-1 prevents the immediate activation of the entire pool of LET-23 EGFR and permits the generation of a long-lasting inductive signal
Title: An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling.
Rab7, by mediating EGFR trafficking and degradation, plays an important role in downregulation of EGFR signaling
Title: RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.
Data show that CDT-2 and CUL-4, members of the CUL-4/DDB-1/CDT-2 E3 ubiquitin ligase complex attenuate LET-23 signalling in vulval precursor cells.
Title: The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.
Results identify EGF receptor(EGFR) Let-23 substrate protein-8 (EPS-8) as a novel component of the EGFR localization complex that links receptor trafficking to cell fate specification.
Title: Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development.
Results demonstrate the existence of a novel pathway for promoting epidermal growth factor receptor-mediated vulval development that involves activation of the heterotrimeric Galphaq protein, EGL-30
Title: Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1067.1 (e-PCR)
- UniSTS:308245

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IEA Inferred from Electronic Annotation more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane region	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase

NP_001129830.1

Confirmed by transcript evidence

NP_001129831.1

Confirmed by transcript evidence

NP_001300607.1

Confirmed by transcript evidence

NP_495962.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9197512..9207213

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313678.3 → NP_001300607.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AX35

Conserved Domains (7) summary

smart00219
Location:898 → 1153

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:578 → 625

FU; Furin-like repeats

cd00064
Location:274 → 308

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:229 → 378

Furin-like; Furin-like cysteine rich region

pfam01030
Location:77 → 205

Recep_L_domain; Receptor L domain

pfam14843
Location:531 → 652

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:885 → 1164

PKc_like; Protein Kinases, catalytic domain
NM_001136359.5 → NP_001129831.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129831.1

Status: REVIEWED

UniProtKB/TrEMBL

B5BM27

Conserved Domains (7) summary

smart00219
Location:891 → 1146

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:571 → 618

FU; Furin-like repeats

cd00064
Location:267 → 301

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:222 → 371

Furin-like; Furin-like cysteine rich region

pfam01030
Location:70 → 198

Recep_L_domain; Receptor L domain

pfam14843
Location:524 → 645

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:878 → 1157

PKc_like; Protein Kinases, catalytic domain
NM_063561.5 → NP_495962.2 Receptor tyrosine-protein kinase let-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495962.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P24348

Conserved Domains (7) summary

smart00219
Location:886 → 1141

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:566 → 613

FU; Furin-like repeats

cd00064
Location:262 → 296

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:217 → 366

Furin-like; Furin-like cysteine rich region

pfam01030
Location:65 → 193

Recep_L_domain; Receptor L domain

pfam14843
Location:519 → 640

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:873 → 1152

PKc_like; Protein Kinases, catalytic domain
NM_001136358.4 → NP_001129830.1 receptor protein-tyrosine kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129830.1

Status: REVIEWED

UniProtKB/TrEMBL

B5BM28

Conserved Domains (7) summary

smart00219
Location:825 → 1080

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:505 → 552

FU; Furin-like repeats

cd00064
Location:201 → 235

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:156 → 305

Furin-like; Furin-like cysteine rich region

pfam01030
Location:4 → 132

Recep_L_domain; Receptor L domain

pfam14843
Location:458 → 579

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:812 → 1091

PKc_like; Protein Kinases, catalytic domain