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    rbm-22 Pre-mRNA-splicing factor RBM22 [ Caenorhabditis elegans ]

    Gene ID: 177979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbm-22
    Official Full Name
    Pre-mRNA-splicing factor RBM22
    Primary source
    WormBase:WBGene00011722
    Locus tag
    CELE_T11G6.8
    See related
    AllianceGenome:WB:WBGene00011722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable U6 snRNA binding activity and pre-mRNA binding activity. Located in nucleus. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rbm-22 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (10861402..10864232)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sugar phosphate exchanger 3 Neighboring gene ncRNA Neighboring gene Histidine--tRNA ligase Neighboring gene PX domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
    2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Pre-mRNA-splicing factor RBM22
    NP_001293970.1
    • Confirmed by transcript evidence
    NP_502014.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10861402..10864232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069613.9 → NP_502014.2  Pre-mRNA-splicing factor RBM22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502014.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22412
      Conserved Domains (3) summary
      smart00356
      Location:165 → 188
      ZnF_C3H1; zinc finger
      COG0724
      Location:214 → 322
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12224
      Location:234 → 311
      RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins

    2. NM_001307041.3 → NP_001293970.1  Pre-mRNA-splicing factor RBM22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACS6
    Nucleotide Protein
    Heading Accession and Version

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