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    emb-27 Cell division cycle protein 16 homolog [ Caenorhabditis elegans ]

    Gene ID: 174314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emb-27
    Official Full Name
    Cell division cycle protein 16 homolog
    Primary source
    WormBase:WBGene00001281
    Locus tag
    CELE_F10B5.6
    See related
    AllianceGenome:WB:WBGene00001281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in asymmetric cell division; eggshell formation; and polarity specification of anterior/posterior axis. Located in synapse. Is expressed in GABAergic neurons. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See emb-27 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8159865..8162170, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tubby protein homolog 1 Neighboring gene Transmembrane protein 138 Neighboring gene Putative pachytene checkpoint protein 2 Neighboring gene RNA-directed RNA polymerase Neighboring gene Uncharacterized protein Neighboring gene Venom protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans. Wang J, et al. PeerJ, 2016. PMID 27190716, Free PMC Article
    2. Born again at the synapse: a new function for the anaphase promoting complex/cyclosome. Zarnescu DC, et al. Dev Cell, 2004 Dec. PMID 15572119
    3. Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos. Strome S, et al. Cell, 1983 Nov. PMID 6684994
    4. Total RNA, rRNA and poly(A)+RNA abundances during aging in Caenorhabditis elegans. Fabian TJ, et al. Mech Ageing Dev, 1995 Sep 15. PMID 8583834
    5. Anucleate Caenorhabditis elegans sperm can crawl, fertilize oocytes and direct anterior-posterior polarization of the 1-cell embryo. Sadler PL, et al. Development, 2000 Jan. PMID 10603352

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell division cycle protein 16 homolog
    NP_495712.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8159865..8162170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063311.10 → NP_495712.1  Cell division cycle protein 16 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495712.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EG38
      Conserved Domains (4) summary
      smart00028
      Location:498 → 528
      TPR; Tetratricopeptide repeats
      TIGR02552
      Location:346 → 443
      LcrH_SycD; type III secretion low calcium response chaperone LcrH/SycD
      sd00006
      Location:498 → 523
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:498 → 560
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EG38.1

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